Antiherpes tetrapeptide derivatives having a cycloalkyl...

Details Antiherpes tetrapeptide derivatives having a cycloalkyl... Antiherpes tetrapeptide derivatives having a cycloalkyl...

C - Chemistry, Metallurgy

07

K

530/5.1, 167/103

C07K 5/04 (2006.01) A61K 38/04 (2006.01) C07K 5/10 (2006.01)

Patent

CA 2019006

Disclosed herein are tetrapeptide derivatives of the formula X-NH-CHR1-C(W1)-NR2-CH[CH2C(O)-Y]-C(W2)-NH-CH[CR3(R5)- COON]-C(W3)-NH-CHR5-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 and R5 are selected from amino acid or derived amino acid residues, R2 is hydrogen, alkyl or phenylalkyl, R3 and R4 are joined to form a cycloalkyl, W1, W2 and W3 are oxo or thioxo, Y is, for example, an alkoxy or a monosubstituted or disubstituted amino, and Z is a terminal unit, for example, hydrogen, COON or CH2OH. The derivatives are useful for treating herpes infections.

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