Inhibition of apoptosis in cells expressing fas-ligand...

Details Inhibition of apoptosis in cells expressing fas-ligand... Inhibition of apoptosis in cells expressing fas-ligand...

A - Human Necessities

61

K

A61K 31/20 (2006.01) A61K 31/07 (2006.01) A61K 31/203 (2006.01) C12N 5/12 (2006.01) C12Q 1/02 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2218685

Method for mediating the expression by mammalian cells of Fas-Ligand following activation using retinoid compounds, and specifically retinoid compounds which activate both retinoid X receptors and retinoic acid receptors. Examples of such retinoid compounds are 9-cis retinoic acid and related compounds. The method provides a means for inhibiting apoptosis in cells which express Fas-Ligand following activation.

Procédé d'induction de l'expression de ligands de FAS par des cellules de mammifères après activation à l'aide de composés de rétinoïde et plus particulièrement de composés de rétinoïde activant à la fois les récepteurs du rétinoïde X et de l'acide rétinoïque. L'acide 9-cis rétinoïque et les composés associés constituent des exemples de ces composés de rétinoïde. Ce procédé permet d'obtenir un moyen d'inhiber l'apoptose dans des cellules exprimant des ligands de FAS après activation.

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