Substituted amino alkyl compounds

Details Substituted amino alkyl compounds Substituted amino alkyl compounds

C - Chemistry, Metallurgy

07

D

C07D 473/04 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01)

Patent

CA 2117377

Compounds and pharmaceutical compositions thereof comprise the formula: (R)j - (core moiety), including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, wherein j is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-membered ring structure, R may be selected from the group consisting of hydrogen, halogen, hydroxyl, amino substituted or unsubstituted benzyl, alkyl (C1-6) or alkenyl (C1-6), and at least one R has formula (I), wherein n is an integer from four to eighteen; each R'1 and R'2 is independently hydrogen, alkyl (C1-4) or alkenyl (C1-4), the alkyl or alkenyl groups being preferably substituted by a halogen, hydroxyl, ketone or dimethylamino group and/or may be interrupted by an oxygen or hydrogen atom or an alkyl (C1- 4) group; and each R'3 and R'4 is independently hydrogen or methyl. Preferably, n is an integer from six to ten, R'1 and R'2 are independently hydrogen or methyl and R'3 and R'4 are hydrogen. The compounds are useful in treating or preventing, for example, sepsis syndrome, hematopoietic or organ toxicity, baldness, hair loss or allopecia caused by cytotoxic therapies, and progression of an inflammatory or autoimmune disease.

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