Nonpeptides as tachykinin antagonists

Details Nonpeptides as tachykinin antagonists Nonpeptides as tachykinin antagonists

C - Chemistry, Metallurgy

07

C

C07C 275/24 (2006.01) A61K 31/17 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 45/68 (2006.01) C07C 205/42 (2006.01) C07C 205/43 (2006.01) C07C 271/22 (2006.01) C07C 271/34 (2006.01) C07C 275/10 (2006.01) C07D 209/20 (2006.01) C07D 213/56 (2006.01) C07D 233/61 (2006.01) C07D 307/79 (2006.01) C07D 307/81 (2006.01) C07D 333/24 (2006.01) C07D 333/60 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2211191

The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, addiction disorders, inflammatory diseases, gastrointestinal disorders, vascular disorders, and neuropathological disorders.

L'invention porte sur de petits non peptides qui sont des antagonistes de la tachykinine. Ces composés sont des antagonistes NK¿3? hautement sélectifs et fonctionnels dont on pense qu'il sont utiles dans le traitement de la douleur, de la dépression, de l'anxiété, de la panique, de la schizophrénie, des névralgies, des troubles liés à l'accoutumance, des maladies inflammatoires, des troubles gastrointestinaux, des troubles vasculaires et des troubles neuropathologiques.

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