Prostate cancer gene

Details Prostate cancer gene Prostate cancer gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2311416

The present invention relates to PG1, a gene associated with prostate cancer. The invention provides polynucleotides including biallelic markers derived from PG1 and from flanking genomic regions. Primers hybridizing to these biallelic markers and regions flanking are also provided. This invention provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and prostate cancer and between a haplotype and prostate cancer. The invention also relates to diagnostic methods of determining whether an individual is at risk for developing prostate cancer, and whether an individual suffers from prostate concer as a result of a mutation in the PG1 gene.

L'invention concerne un gène PG1, associé au cancer de la prostate. L'invention concerne également des polynucléotides comprenant des marqueurs biallèles dérivés du PG1 et de régions génomiques flanquantes. L'invention concerne en outre des amorces capables d'hybridation avec les marqueurs et les régions en question. L'invention concerne par ailleurs des polynucléotides et des procédés appropriés au génotypage d'un échantillon à base d'acide nucléique correspondant à un ou à plusieurs marqueurs biallèles décrits. Enfin, l'invention concerne des procédés permettant de déceler une corrélation statistique entre un allèle à marqueur biallèle et un cancer de la prostate, d'une part, et entre un haplotype et un cancer de la prostate, d'autre part, ainsi que des procédés diagnostiques visant à déterminer si un individu risque de présenter un cancer de la prostate et si un individu est atteint de ce cancer suite à une mutation du gène PG1 considéré.

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