G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/00 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2491540
The present invention provides methods of suppressing demyelinating inflammatory disorders in a patient by administering to the patient a compound that inhibits binding of B7RP-1 to ICOS or inhibits signaling through the B7RP- 1 pathway. Various therapeutic regimens are provided. Methods of identifying such compounds are also provided. The present invention further provides kits and pharmaceutical compositions useful in the present methods.
La présente invention concerne des procédés pour combattre les troubles inflammatoires de démyélinisation par l'administration au patient d'un composé qui inhibe la liaison de B7RP-1 à ICOS ou la signalisation par la voie de signalisation B7RP-1. Elle porte sur divers régimes thérapeutiques ainsi que sur divers procédés pour identifier ces composés. La présente invention concerne aussi des kits et des compositions pharmaceutiques utilisés avec ces procédés.
Kroczek Richard A.
Rottman James B.
Bundesrepublik Deutschland Letztvertreten Durch Den Direktor Des
Millennium Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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