Aryl/alkyl vinyl sulfone hyaluronic acid derivatives

Details Aryl/alkyl vinyl sulfone hyaluronic acid derivatives Aryl/alkyl vinyl sulfone hyaluronic acid derivatives

C - Chemistry, Metallurgy

08

B

C08B 37/08 (2006.01) A61K 8/73 (2006.01) A61K 31/728 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2643714

A hyaluronic acid derivative, and methods of producing and using said derivative, the derivative comprising n repeating units and having the general structural formula (I), wherein, in at least one repeating unit, one or more of R1, R2, R3, R4 comprises an etherbound aryl/alkyl sulfone having the general structural fomula (II), wherein R comprises an alkyl- or aryl-group, and otherwise R1, R2, R3, R4 are hydroxyl groups, OH.

L'invention concerne un dérivé de l'acide hyaluronique ainsi que des procédés de production et d'utilisation dudit dérivé. Le dérivé comprend n motifs répétés et il répond à la formule structurelle générale (I) dans laquelle, dans l'un au moins des motifs répétés, un ou plusieurs radicaux R1, R2, R3, R4 comprennent un (aryl/alkyl)sulfone lié à un éther et répondant à la formule structurelle générale (II), dans laquelle R comprend un groupe alkyle ou aryle ; et R1, R2, R3, R4 sont autrement des groupes OH (hydroxyle).

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