C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2634286
The disclosure provided herein provides for methods and compositions for modulating the human complement pathway by reducing the expression or production of one or more complement pathway protein and uses for such methods for treating diseases including ocular disease and macular degeneration related disease. The invention also includes active agents for mediating the modulation of the complement pathway including siRNA designed to cause the RNAi- mediated degradation of complement pathway proteins.
L'invention concerne des procédés et des compositions pour moduler la voie du complément humain par réduction de l'expression ou de la production d'une ou de plusieurs protéines de la voie du complément, ainsi que des utilisations de ces procédés pour traiter des maladies, notamment une maladie oculaire et une maladie liée à la dégénérescence maculaire. L'invention concerne également des agents actifs destinés à médier la modulation de la voie du complément, notamment le petit ARN interférent destiné à provoquer la dégradation de protéines de la voie du complément médiée par interférence ARN.
Dejneka Nadine
Reich Samuel Jotham
Borden Ladner Gervais Llp
Opko Ophthalmics Llc
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