Substituted bicyclic piperidinyl- and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 451/04 (2006.01) A61K 31/33 (2006.01) A61P 5/00 (2006.01) C07D 491/08 (2006.01)

Patent

CA 2696285

In its many embodiments, the present invention relates to a novel class of substituted bicyclic piperidinyl- and piper-azinylsulfonamide compounds useful to inhibit 11.beta.-hydroxysteroid dehydrogenase type-I, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11.beta.-hydroxysteroid dehydrogenase type-I using such compounds or pharmaceutical compositions.

Cette invention a trait à une nouvelle classe de composés sulfonamides de pipéridinyle et de pipérazinyle bicycliques substitués utilisés pour inhiber la 11ß-hydroxystéroïde déshydrogénase de type-1, à des compositions pharmaceutiques contenant ces composés, et à des procédés de traitement, de prévention, d'inhibition ou d'amélioration d'une ou de plusieurs pathologies associées avec l'expression de la 11ß-hydroxystéroïde déshydrogénase de type-1 utilisant ces composés ou ces compositions pharmaceutiques.

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