Method for determining expression of aberrant forms of apc...

Details Method for determining expression of aberrant forms of apc... Method for determining expression of aberrant forms of apc...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2264054

A group of proteins which are associated with T cell activation are disclosed, as are the nucleic acid molecules encoding them. Various uses of these materials are also discussed, such as in determining presence or absence of aberrant forms of APC protein. This determination can be used to determine predisposition toward colorectal cancer, or as a diagnosis of this condition. The nucleic acid molecules encoding these proteins are also disclosed.

Groupe de protéines associées à l'activation des lymphocytes T et molécules d'acide nucléique codant ces protéines. L'invention présente également diverses utilisations de ces substances, notamment pour déterminer la présence ou l'absence de formes aberrantes de protéine APC. Cette méthode de repérage peut être utilisée pour détecter une prédisposition au cancer colorectal, ou établir un diagnostic de cette maladie. L'invention porte également sur des molécules d'acide nucléique codant ces protéines.

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