Citalopram hydrobromide crystal and method for...

Details Citalopram hydrobromide crystal and method for... Citalopram hydrobromide crystal and method for...

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01)

Patent

CA 2343543

According to the present invention, citalopram hydrobromide dissolved in a solvent containing at least one member selected from the group consisting of alcohol having 1 - 3 carbon atoms, water and acetone is crystallized or recrystallized while controlling the cooling rate, thereby to 1) provide an industrial method for crystallizing citalopram hydrobromide, which enables easy control of the crystal characteristics, such as particle size, particle size distribution and aspect ratio and the like of the crystal, and 2) provide citalopram hydrobromide crystal having crystal characteristics useful as a pharmaceutical bulk.

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