C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2700599
The invention relates to pyrazolo-pyrazines derivatives of the general formula (I) in which the radicals Z, R1, R2, R3 and R4 represent various variable groups, X is a sulphur atom or a selenium atom, and n is an integer equal to 1 or 2. These compounds are inhibitors of G proteins. They are of particular interest for treating diseases in which the heterotrimeric G protein is involved. The invention also relates to pharmaceutical compositions containing said products, and to the use thereof for preparing a drug.
La présente invention a pour objet des dérivés des pyrazolo-pyrazines de formule générale (Formula I) dans laquelle les radicaux Z, R1, R2, R3 et R4 représentent divers groupes variables, X un atome de souffre ou un atome de sélénium et n représente le nombre entier 1 ou 2. Ces composés sont des inhibiteurs de protéines G. Ils sont donc particulièrement intéressants pour traiter des pathologies qui résultent de l'implication de la protéine G hétérotrimérique. L'invention concerne également des compositions pharmaceutiques contenant lesdits produits et leur utilisation pour la préparation d'un médicament.
Brehu Laetitia
Lavergne Olivier
Prevost Gregoire
Goudreau Gage Dubuc
Ipsen Pharma S.a.s.
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