Novel method and compositions

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/16 (2006.01) A61K 39/00 (2006.01) C07K 14/445 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2679410

The present invention relates to, inter alia, a method of raising an immune response against a pathogen which comprises administering (i) one or more first immunogenic polypeptides derived from said pathogen; (ii) one or more adenoviral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from said pathogen; and (iii) an adjuvant; wherein the one or more first immunogenic polypeptides, the one or more adenoviral vectors and the adjuvant are administered concomitantly. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing said polypeptides, adenoviral vectors and adjuvants.

La présente invention a pour objet, entre autres, un procédé de déclenchement d'une réponse immunitaire contre un agent pathogène qui comprend l'administration (i) d'un ou plusieurs premiers polypeptides immunogéniques dérivés dudit agent pathogène ; (ii) d'un ou plusieurs vecteurs adénoviraux comprenant un ou plusieurs polynucléotides hétérologues codant pour un ou plusieurs seconds polypeptides immunogéniques dérivés dudit agent pathogène ; et (iii) d'un adjuvant ; où le ou les premiers polypeptides immunogéniques, le ou les vecteurs adénoviraux et l'adjuvant sont administrés simultanément. L'invention concerne également des vaccins, des compositions pharmaceutiques, des kits et des utilisations employant lesdits polypeptides, vecteurs adénoviraux et adjuvants.

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