Stem cells derived from the carotid body and uses thereof

Details Stem cells derived from the carotid body and uses thereof Stem cells derived from the carotid body and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 5/074 (2010.01) C12N 5/071 (2010.01) C12N 5/079 (2010.01) A61K 35/12 (2006.01) A61K 35/30 (2006.01)

Patent

CA 2695256

Adult stem cells obtained from the carotid body, characterized in that they are positive for the phenotypic marker GFAP (glial fibrillary acidic protein) and negative for the phenotypic markers TH (tyrosine hydroxylase) and nestin, are described. These stem cells can undergo proliferation, self-renewal and differentiation to progenitor cells and differentiated cells. Said stem cells, progenitor cells and differentiated cells, expanded by any method, can be used in the treatment of neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease.

La présente invention concerne des cellules souches adultes provenant du glomus carotidien, qui se caractérisent en ce qu'elles sont positives au marqueur phénotypique GFAP (protéine gliale fibrillaire acide) et négatives aux marqueurs phénotypiques TH (tyrosine hydroxylase) et à la nestine. Ces cellules souches peuvent proliférer, se renouveler d'elles-mêmes et se différencier en cellules progénitrices et différenciées. Lesdites cellules souches, cellules progénitrices et cellules différenciées, développées au moyen de n'importe quel procédé, peuvent s'utiliser lors du traitement de maladies neurodégénératives telles que la maladie d'Alzheimer ou la maladie de Parkinson.

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