Sulfonamide derivatives as 5ht7 receptor antagonists

Details Sulfonamide derivatives as 5ht7 receptor antagonists Sulfonamide derivatives as 5ht7 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/14 (2006.01) A61K 31/445 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2531787

The present invention discloses a compound of formula (I): - wherein A is an aromatic moiety or selected from benzyl, C1-C16 alkyl dialkylamino, dialkylaminoalkyl, alkoxyalkyl, cyano, and mono-, di-, or tri-hydroxyalkyl and/or aryl, B is an aromatic moiety, R1 and R2 are independently C1 to C6 alkyl or NR1R2 forms a 5 to 8 membered ring optionally containing one or two additional heteroatoms selected from nitrogen, oxygen and sulphur and which is optionally substituted by C1 to C6 alkyl, and n is 0 or 1, and salts and hydrates thereof. The invention is also concerned with methods of synthesising the compounds and their uses as 5-HT7 ligands.

La présente invention concerne un composé de formule (I) et les sels et hydrates dudit composé. Dans ladite formule, A représente un fragment aromatique ou est sélectionné dans le groupe constitué par benzyle, alkyle C¿1?-C¿16?, dialkylamino, dialkylaminoalkyle, alcoxyalkyle, cyano, et mono-, di- ou tri-hydroxyalkyle et/ou aryle; B est un fragment aromatique; R¿1? et R¿2? sont indépendamment alkyle C¿1? à C¿6?, ou NR¿1?R¿2? forme un noyau de 5 à 8 chaînons contenant éventuellement un ou deux hétéroatomes sélectionnés dans le groupe constitué par azote, oxygène et soufre et éventuellement substitués par alkyle C¿1? à C¿6?; et n représente 0 ou 1. L'invention concerne en outre des méthodes de synthèse des composés, et l'utilisation des composés comme ligands de 5-HT¿7?

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