Nanoparticulate imatinib mesylate formulations

Details Nanoparticulate imatinib mesylate formulations Nanoparticulate imatinib mesylate formulations

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/506 (2006.01)

Patent

CA 2610448

The present invention is directed to a nanoparticulate compositions of imatinib mesylate, or a salt or derivative thereof, having improved pharmacokinetic profiles and reduced fed/fasted variability. The nanoparticulate imatinib mesylate particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of chronic myeloid leukemia, gastrointestinal stromal tumors and related diseases.

L'invention concerne des compositions nanoparticulaires d'imatinib mesylate ou un sel ou un dérivé de celui-ci, présentant des profils pharmacocinétiques améliorés et une variabilité alimenté/à jeun réduite. Les particules d'imatinib mesylate nanoparticulaires de la composition possèdent une granulométrie moyenne efficace inférieure à environ 2000 nm et sont utiles dans le traitement de la leucémie myéloïde chronique, les tumeurs du stroma gastro-intestinal et des maladies associées.

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