Use of nadph oxidase inhibitors for the manufacture of a...

Details Use of nadph oxidase inhibitors for the manufacture of a... Use of nadph oxidase inhibitors for the manufacture of a...

C - Chemistry, Metallurgy

12

Q

C12Q 1/26 (2006.01) A61P 9/10 (2006.01) C12Q 1/00 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2309881

A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothetial cells to atherogenic LDL levels, thus resulting in decreased endocytosis and vascular hyperpermeability. Preferred NADPH oxidase inhibitors are of formula (I). Additionally, there is provided a diagnostic method for predicting risk of a human patient to atherosclerosis-related diseases.

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