Novel modulators of protein kinase signaling

Details Novel modulators of protein kinase signaling Novel modulators of protein kinase signaling

C - Chemistry, Metallurgy

07

C

C07C 327/44 (2006.01) A61K 31/16 (2006.01) A61K 31/426 (2006.01) C07D 277/16 (2006.01)

Patent

CA 2758016

The present invention provides new tyrphostin derivatives acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for preventions and treatments of PK and RK related disorders such as metabolic, inflammatory, fibrotic, and cell proliferative disorders, in particular cancer.

L'invention concerne de nouveaux dérivés de tyrphostine agissant comme des modulateurs de la signalisation de protéines kinases (PK) et de récepteurs kinases (RK). Elle concerne en outre des procédés de préparation de ces dérivés, des compositions pharmaceutiques comprenant de tels composés et des procédés d'utilisation de ces composés et compositions, notamment comme agents chimiothérapeutiques destinés à prévenir ou à traiter des troubles associés aux PK et aux RK tels que des troubles métaboliques, inflammatoires et fibrotiques, ainsi que des troubles de la prolifération cellulaire, en particulier le cancer.

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