A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 31/496 (2006.01)
Patent
CA 2258683
A pharmaceutical composition comprising: i) substantially inert beads; wherein said beads are coated with ii) an antifun- gal agent which is (-)-(2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluorophenyl)- tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1- piperazinyl]phenyl)-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxypropyl]-3H-1,2,4- triazol-3-one; iii) a binder to enable the antifungal compound to adhere to said beads. The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavail- ability in mammals, such as humans.
Composition pharmaceutique comprenant: i) des perles sensiblement inertes qui sont enrobées ii) d'un agent antifongique qui est (-)-(2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluorophényl)-tétrahydro-5-(1H-1,2,4-triazol-1-ylméthyl)furan-3-yl]méthoxy]phényl]-1-pipérazinyl]phényl]-2,4-dihydro-2-[(S)-1-éthyl-2(S)-hydroxypropyl]-3H-1,2,4-triazol-3-one; iii) un liant permettant au composé antifongique d'adhérer auxdites perles. La composition permet au composé antifongique, qui possède une très faible solubilité dans l'eau, d'avoir une meilleure biodisponibilité chez les mammifères tels que les êtres humains.
Lee Ping I.
Sangekar Surendra A.
Vadino Winston A.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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