C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/20 (2006.01) A61K 31/18 (2006.01) A61P 19/02 (2006.01) A61P 35/04 (2006.01) C07C 311/29 (2006.01) C07C 311/43 (2006.01)
Patent
CA 2560739
Disclosed are selective inhibitors of matrix metalloproteinases represented by the following formula (I). wherein X is (CH2)nO, (CH2)nS, (CH2)nNR1, (CH2)n(CH2), or CH=CH, wherein n = 0, 1, or 2; R and R1 are, independently, a substituted or unsubstitued alkyl, alkenyl, alkynyl, aryl, heteroaryl group, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl; and Z is NH or CH2; or a pharmaceutically acceptable salt thereof. Also disclosed are methods of making such compounds and methods of using such compounds to inhibit tumor progression and to treat diseases such as arthritis.
Des inhibiteurs sélectifs de métalloprotéinases matricielles représentées par la formule suivante (I),dans laquelle X désigne (CH¿2?)¿n?O, (CH¿2?)¿n?S, (CH¿2?)¿n?NR?1¿, (CH¿2?)¿n?(CH¿2?), ou CH=CH, où n = 0, 1, ou 2; R et R?1¿ désignent, indépendamment, alkyle, alcényle, alkynyle, aryle, groupe hétéroaryle, cycloalkyle, hétérocycloalkyle, cycloalcényle ou hétérocycloalcényle substitué ou non; et Z désigne NH ou CH¿2?; ou leurs sels pharmaceutiquement acceptables. Des procédés de fabrication de tels composés et des procédés d'utilisation de tels composés permettant d'inhiber la progression d'une tumeur et de traiter les maladies, notamment l'arthrite.
Smart & Biggar
Southern Research Institute
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