C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/424 (2006.01) A61K 31/437 (2006.01) A61K 31/454 (2006.01) A61P 25/18 (2006.01) C07D 498/14 (2006.01)
Patent
CA 2738254
The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
La présente invention concerne des dérivés doxazolobenzimidazole qui sont des potentialisateurs de récepteurs métabotropiques de glutamate, en particulier le récepteur mGluR2, et qui sont utiles dans le traitement ou la prévention de troubles neurologiques et psychiatriques associés à un dysfonctionnement du glutamate et de maladies dans lesquelles les récepteurs métabotropiques de glutamate sont impliqués. Linvention concerne en outre des compositions pharmaceutiques comprenant ces composés et lutilisation de ces composés et compositions dans la prévention ou le traitement de maladies dans lesquelles les récepteurs métabotropiques de glutamate sont impliqués.
Converso Antonella
Hartingh Timothy John
Stachura Sylwia
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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