Triazole compounds and the use thereof

Details Triazole compounds and the use thereof Triazole compounds and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) C07D 249/08 (2006.01) C07D 249/12 (2006.01) C07D 249/14 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2195243

The present invention relate to triazole compounds of formula (I) in which R1, R2 stand for H or different substituents, A stands for a bivalent group, B stands for a test of the formula (a), (b) or (c) and Ar stands for optionally substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of disease responding to dopamine-D3-ligands.

L'invention concerne des composés triazole de la formule (I) dans laquelle R<1> et R<2> désignent H ou différents substituants, A désigne un groupe bivalent, B désigne un reste de la formule (a), (b) ou (c) et Ar désigne phényle, pyridyle, pyrimidyle ou triazinyle éventuellement substitué. Ces composés présentent une grande affinité à l'égard du récepteur de la dopamine-D3 et s'utilisent par conséquent dans le traitement d'affections réagissant à des ligands de la dopamine-D3.

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