Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents

Details Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents

C - Chemistry, Metallurgy

07

F

C07F 9/6584 (2006.01) A61K 33/40 (2006.01) A61K 33/42 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2753041

The present disclosure concerns complexes of 4-hydroperoxy ifosfamide. In one embodiment the complexes can be represented by the formula (A); wherein A represents an ammonium species selected from the conjugate acid of a basic amino acid, quaternary ammonium, aliphatic ammonium, heterocyclic ammonium, aromatic ammonium, substituted and unsubstituted pyridinium, guanidinium, and amidinium, and wherein X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.

La présente invention concerne des complexes du 4-hydropéroxy-ifosamide. Dans un mode de réalisation, les complexes peuvent être représentés par la formule (A) ; dans laquelle A représente une espèce d'ammonium choisie parmi un acide conjugué d'un acide aminé basique, un ammonium quaternaire, un ammonium aliphatique, un ammonium hétérocyclique, un ammonium aromatique, un pyridinium substitué et non substitué, un guanidinium, et un amidinium, et dans laquelle X et Y représentent indépendamment des groupes partants. L'invention concerne également des procédés de fabrication de tels composés et leur formulation dans des compositions pharmaceutiques. L'invention concerne également des procédés d'administration des composés décrits à des sujets, en particulier dans le but de traiter des troubles hyper-prolifératifs.

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