Parathyroid hypertensive factor

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/275 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) A61K 31/59 (2006.01) A61K 35/55 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2288407

A new circulating factor from the parathyroid gland of some hypertensive mammals has been isolated and characterized. Polyclonal and monoclonal antibodies raised against this factor are usable as a screen for the presence of the factor. The factor is involved in the control of calcium uptake in cells. Hypertensive mammals may be treated to lower mean blood pressure by administering a calcium channel blocking agent together with one or both of a calcium supplement and Vitamin D. The hypotensive effect of this combination is synergistic and the dose response is more predictable than the administration of any of these agents singly.

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