Compositions for eliciting an immune response against...

A - Human Necessities – 61 – K

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A61K 39/04 (2006.01) A61K 39/00 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2704178

Provided are compositions and methods for stimulating an immune response against Mycobacterium avium subspecies paratuberculosis (MAP). The compositions include a recombinant polypeptide that contains from its N-terminus to C-terminus a C-terminal fragment of MAP protein Map3527, a Map1519 protein amino acid sequence, followed by an N-terminal portion of Map3527. The method comprises administering the composition to an animal in an amount effective to stimulate an immunological response against MAP bacteria. The method is of benefit to any animal susceptible to MAP infection, but is particularly beneficial for ruminants.

L'invention concerne des compositions et procédés pour stimuler une réponse immunitaire contre une paratuberculose de sous-espèce aviaire de microbactéries (MAP). Les compositions comprennent un polypeptide recombinant qui contient de son extrémité N-terminale à son extrémité C-terminale un fragment C-terminal de protéine MAP Map3527, une séquence d'acides aminés de protéine Map1519, suivi par une partie N-terminale de Map3527. Le procédé comprend l'administration de la composition à un animal en une quantité efficace pour stimuler les réponses immunologiques contre des bactéries MAP. Le procédé présente également un bénéfice sur tout animal prédisposé à une infection par MAP, mais est particulièrement bénéfique pour les ruminants.

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