Therapeutic agents

Details Therapeutic agents Therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 491/052 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 231/22 (2006.01) C07D 311/22 (2006.01) C07D 335/06 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2074841

2074841 9111448 PCTABS00006 Compounds of formula (I) in which X represents oxygen or sulphur; Z represents -CH= or -N= when X represents oxygen; Z represents -CH= when X represents sulphur; R5 represents hydrogen when R3 represents methyl, or R5 represents (a), when R3 represents a bond together with either one of R2 and R4; R6 represents hydrogen, halo, S(O)nY1, carboxy, carbamoyl, a carboxylic acyl group, an esterified carboxyl group or CONR12R13; R6' represents hydrogen or methyl; or R6 and R6' together with the carbon atom to which they are attached represent cyclopropyl; R9 and R10, which may be the same or different, represent halo; or R9 represents hydrogen and R10 represents hydrogen, halo, trifluoromethyl, nitro, C1-6 alkyl, C1-6 alkoxy, hydroxy or a carboxylic acyloxy group; R12 represents methyl, ethyl or C3-8 cycloalkyl and R13 represents C1-6 alkyl optionally substituted by cyano, phenyl, a 3-8 membered non-aromatic heterocyclic group, a 5 or 6 membered heterocyclic aryl group or C3-8 cycloalkyl; or R13 represents phenyl optionally substituted by C2-6 alkoxycarbonyl or halo; or R12 and R13 together with the nitrogen to which they are attached represent a 3-8 membered non-aromatic heterocyclic group which may be substituted by a C2-6 acyloxy(C1-6)alkyl group; Y1 represents C1-6 alkyl; n is 0, 1 or 2, and R1, R2, R4, R7, R8 and R8' are as defined, for use as immunomodulatory agents.

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