A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2710483
Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This deminished adhesion renders the tumor cells not only susceptible to the immunconjugate, but also to other agents, in particular cytotoxic agents.
La présente invention concerne des immunoconjugués ayant une spécificité envers CD138 qui diminuent l'adhésion des cellules tumorales exprimant CD138 aux cellules stromales, et des procédés permettant de les utiliser. Cette adhésion diminuée rend les cellules tumorales sensibles non seulement à l'immunoconjugué mais également à d'autres agents, en particulier à des agents cytotoxiques.
Anderson Kenneth
Bruecher Christoph
Daelken Benjamin
Hideshima Teru
Uherek Christoph
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biotest Ag
Dana-Farber Cancer Institute Inc.
Immunogen Inc.
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