C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2541100
The invention concerns quinazoline derivatives of Formula (I) wherein each of R1, R3, R20, X1, X2, Z, W, (a) and (q) have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of turnours which are sensitive to inhibition of erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.
L'invention porte sur des dérivés de quinazoline de Formule (I) dans laquelle chacun des R?1¿, R?3¿, R?20¿, X?1¿, X?2¿, Z, W, (a) et (q) sont tels que définis dans le descriptif; sur leurs procédés de préparation, sur des compositions pharmaceutiques les contenant et sur leur utilisation dans la fabrication d'un médicament destiné à être utilisé comme agent antiprolifératif dans la prévention ou le traitement de tumeurs qui sont sensibles à l'inhibition des tyrosine kinases du récepteur erbB, notamment la tyrosine kinase EGFR.
Halsall Christopher Thomas
Hennequin Laurent Francois Andre
Astrazenca Ab
Fetherstonhaugh & Co.
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