Sodium channel inhibitors

Details Sodium channel inhibitors Sodium channel inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/427 (2006.01) A61P 25/00 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2693588

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compos i-tiona comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel. Formula (II)

L'invention concerne des composés, des compositions et des méthodes utiles dans le traitement de maladies par le biais de l'inhibition de flux d'ions sodium dans des canaux sodiques sensibles au voltage. L'invention concerne plus particulièrement des sulfonamides substitués, des compositions contenant ces composés, ainsi que des méthodes d'utilisation de ces composés et compositions dans le traitement de troubles du système nerveux central ou périphérique, en particulier la douleur et la douleur chronique, par le blocage des canaux sodiques associés à l'apparition ou à la récurrence de ces affections. Les composés, compositions et méthodes selon l'invention sont particulièrement utiles dans le traitement de la douleur neuropathique ou inflammatoire par l'inhibition du flux d'ions traversant un canal sodique sensible au voltage.

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