Methods for generating hypermutable yeast

Details Methods for generating hypermutable yeast Methods for generating hypermutable yeast

C - Chemistry, Metallurgy

12

N

C12N 15/81 (2006.01) C12N 5/10 (2006.01) C12N 15/01 (2006.01)

Patent

CA 2399191

Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of desired mutant yeast strains, they can be rendered genetically stable by restoring the mismatch repair system to proper functionality.

Des cellules de levure sont mutagénisées pour obtenir des mutants requis. La mutagénèse est induite par un système défecteux de réparation des mésappariements qui peut être amélioré à l'aide de mutagènes appliqués de manière exogène traditionnelle. Les cellules de levure pourvues du système défecteux de réparation des mésappariements présentent une hyper mutabilité mais après la sélection des souches de levures mutantes requises, il est possible de les rendre génétiquement stables en restaurant la fonctionalité correcte dudit système de réparation.

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