Substituted quinolin-2(1h)-ones useful as hiv reverse...

Details Substituted quinolin-2(1h)-ones useful as hiv reverse... Substituted quinolin-2(1h)-ones useful as hiv reverse...

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/47 (2006.01) C07D 215/227 (2006.01) C07D 215/54 (2006.01)

Patent

CA 2333643

This invention relates generally to quinolin-2(1H)-ones and derivatives thereof of Formula (I) or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, pharmaceutical compositions and diagnostic kits comprising the same, methods of using the same for treating viral infection or as assay standards or reagents, and intermediates and processes for making the same.

L'invention concerne, de manière générale, des quinoline-2(1H)-ones et leurs dérivés, de formule (I), ou des formes ou des mélanges stéréoisomères de celles-ci, ou leurs formes de sels pharmaceutiquement acceptables, lesquels composés sont utiles comme inhibiteurs de la transcriptase inverse du VIH. L'invention concerne également des compositions pharmaceutiques et des kits de diagnostic les comprenant, ainsi que leurs méthodes d'utilisation pour traiter les infections virales ou comme solutions étalon ou réactifs de dosage, et leurs intermédiaires et procédés de fabrication.

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