C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 293/00 (2006.01) A61K 9/51 (2006.01) A61K 31/765 (2006.01) A61K 47/32 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2523987
The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.
L'invention concerne un copolymère séquencé amphiphile constitué d'une séquence hydrophile et d'une séquence hydrophobe comportant un groupe hydroxyle terminal, le groupe hydroxyle terminal de la séquence hydrophobe étant substitué par un groupe tocophérol ou cholestérol. L'invention concerne également des compositions polymères pouvant former des micelles stables dans une solution aqueuse, ces compositions comprenant ledit copolymère séquencé amphiphile et un dérivé d'acide polylactique. Une ou plusieurs extrémités dudit acide polylactique sont liées de façon covalente à au moins un groupe carboxyle.
Chang Dong-Hoon
Choi In-Ja
Hyun Myung-Han
Kim Bong-Oh
Kim Jeong-Kyung
Robic
Samyang Corporation
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