Hdl-binding proteins

Details Hdl-binding proteins Hdl-binding proteins

C - Chemistry, Metallurgy

12

N

530/13, 195/1.11

C12N 15/12 (2006.01) C07K 4/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2003316

56 HDL-BINDING PROTEINS Abstract of the Disclosure Substantially pure mammalian proteins having the following characteristics are disclosed: (a) molecular weight of approximately 110,000 Daltons; (b) bind HDL3; (c) bind apoA-I proteoliposomes and apoA-II protecliposomes; and (d) contain approximately 10% carbohydrate by weight. The present invention also discloses a substantially pure protein having the following characteristics: (a) a molecular weight of approximately 38,000 Daltons; (b) binds HDL3; and (c) contains approximately 331 amino acid residues. DNA sequences encoding these proteins, as well as cells transfected or transformed with an expression vector containing such a DNA sequence are also disclosed. Antibodies that bind to these proteins, methods for isolating an HDL3- binding protein and methods for detecting a genetic defect in an HDL-binding protein in a patient are also disclosed.

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