Cddo-compounds and combination therapies thereof

Details Cddo-compounds and combination therapies thereof Cddo-compounds and combination therapies thereof

A - Human Necessities

61

K

A61K 31/277 (2006.01) A61K 31/07 (2006.01) A61K 31/203 (2006.01) A61K 31/275 (2006.01) A61K 31/335 (2006.01) A61K 38/17 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2430454

CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapies based on these combination therapies are provided, Also provided are methods to treat graft versus host diseases using the CDDO compounds.

Selon l'invention, des composés CDDO conjointement avec d'autres agents chimiothérapeutiques induisent et potentialisent une cytotoxicité et l'apoptose dans une cellule cancéreuse. Une classe d'agents chimiothérapeutiques comprend des rétinoïdes. L'invention concerne également des thérapies contre le cancer fondées sur ces polythérapies. L'invention concerne, en outre, des procédés permettant de traiter une réaction du greffon contres hôtes au moyen des composés CDDO.

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