A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 35/34 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2275436
The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects at risk of, or afflicted with, loss of or damage to myocardial tissue. The methods involve the administration of certain morphogens, inducers of those morphogens, agonists of the corresponding morphogen receptors, or small molecule morphogenic activators, or implantation of cells induced with those agents. The morphogens useful in the invention include OP1, CBMP-2A (BMP-2), CBMP-2B (BMP-4), and other members of the morphogens family of the TGF.beta. superfamily of growth and differentiation factors.
La présente invention fournit des procédés ainsi que des médicaments pour le traitement des sujets ayant perdu, ou risquent de perdre ou d'endommager leur tissu myocardite. Ces procédés impliquent l'administration de certains morphogènes, d'inducteurs de ces morphogènes, d'agonistes des récepteurs morphogéniques correspondants, ou bine d'activateurs morphogéniques de petites molécules; ou alors, recourir à l'implantation des cellules induites par ces agents. Les morphogènes utiles dans cette invention comprennent OP1, CBMP-2A (BMP-2), CBMP-2B (BMP-4), et d'autres membres de la famille des morphogènes appartenant à la superfamille des facteurs de croissance et de différentiation TGF.beta..
Cohen Charles M.
Sampath Kuber T.
Creative Biomolecules Inc.
Curis Inc.
Mbm Intellectual Property Law Llp
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