Serpulina hyodysenteriae vaccine

Details Serpulina hyodysenteriae vaccine Serpulina hyodysenteriae vaccine

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) A61K 39/002 (2006.01) A61K 39/02 (2006.01) C12N 15/00 (2006.01) C12N 15/31 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2085828

DIR 0499 Bl ABSTRACT According to the present invention a vaccine can be prepared containing a mutant Serpulina hyodysenteriae which is defective in its production of biologically active hemolysin. The mutation by which Serpulina hyodysen- teriae is made defective in its production of hemolytically active hemolysin is established by means of genetical engineering techniques. Such muta- tions comprise e.g. deletion of part or the entire gene coding for hemolysin and/or nucleotide sequences controling the production of hemolysin, or insertion of an extra nucleotide or polynucleotide into the gene encoding hemolysin and/or the nucleotide sequences controling the production of hemolysin, or a combination of said deletion and insertion. These vaccines are useful in the prevention of Serpulina infections in susceptible animals such as swine.

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