C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/88 (2006.01) A61K 31/19 (2006.01) A61K 31/198 (2006.01) A61K 31/381 (2006.01) A61K 38/51 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2149776
The present invention describes methods for using methioninase as an antitumor reagent in anti-methionine chemotherapy. Specifically, methioninase is used to slow or stop cell division which can be enhanced with competitive inhibitors of methionine. In addition, methioninase can be used in combination with anti-mitotic agents to increase the therapeutic effectiveness of the antimitotic by inducing cell cycle synchronization.
Guo Huiyan
Han Qinghong
Lishko Valeryi
Tan Yuying
Xu Mingxu
Anticancer Inc.
Fetherstonhaugh & Co.
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