Process for making amlodipine maleate

Details Process for making amlodipine maleate Process for making amlodipine maleate

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01) A61K 31/4422 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2433288

A process for making amlodipine maleate comprises reacting amlodipine or an acid addition salt thereof with maleic acid under an acidic environment to form an amlodipine maleate product. The process allows for the formation of amlodipine maleate substantially free from amlodipine aspartate.

L'invention concerne un procédé permettant de préparer du maléate d'amlodipine, qui consiste à faire réagir l'amlodipine ou un sel d'addition acide de celle-ci avec de l'acide maléique dans un environnement acide afin de produire du maléate d'amlodipine. Ce procédé permet la préparation d'un maléate d'amlodipine sensiblement exempt d'aspartate d'amlodipine.

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