Napthoquinone derivatives as inhibitors of tau aggregation...

Details Napthoquinone derivatives as inhibitors of tau aggregation... Napthoquinone derivatives as inhibitors of tau aggregation...

A - Human Necessities

61

K

A61K 31/255 (2006.01) A61K 31/12 (2006.01) A61K 31/122 (2006.01)

Patent

CA 2451422

Provided are napthoquinone-type compounds which can be used to modulate the aggregation of protein (e.g. tau) associated with neurodegenerative disease (e.g. Alzheimer's disease). Structure-function characteristics for oxidised and reduced napthoquinone-type compounds, such as menadione-related compounds, are disclosed. The invention further provides methods of treatment or prophylaxis of neurodegenerative diseases and/or clinical dementias based on the compounds.

La présente invention concerne des composés de type napthoquinone qui peuvent être utilisés pour moduler l'agrégation de protéines (par ex. tau) associées à des troubles de neurodégénérescence (par ex. la maladie d'Alzheimer). Cette invention concerne également des caractéristiques structure-fonction pour des composés de type napthoquinone oxydée ou réduite. L'invention a également pour objet des procédés destinés au traitement ou à la prévention de troubles de neurodégénérescence et/ou des démences cliniques se basant sur les composés.

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