Human vascular ibp-like growth factor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2206640

A human Vascular IBP-like growth factor polypeptide (VIGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonists against such polypeptides and their use as a therapeutic to treat atherosclerosis, tumors and scarring are also disclosed. Diagnostic assays for identifying mutations in VIGF nucleic acid sequences and altered levels of the VIGF polypeptide are also disclosed.

L'invention concerne un polypeptide du facteur de croissance humain vasculaire proche de la protéine de fixation du facteur de croissance insulinoïde (VIGF), et un ADN (ARN) codant pour ce polypeptide, ainsi qu'un mode opératoire de production de ce polypeptide par des techniques de recombinaison. Sont également décrits des procédés pour utiliser ce polypeptide en vue de favoriser la cicatrisation ou la régénération tissulaire, et de stimuler la fixation des implants et l'angiogénèse. L'invention concerne également des antagonistes de ces polypeptides et leur utilisation comme agent thérapeutique pour traiter l'athérosclérose, les tumeurs et la formation de cicatrices atrophiques. L'invention concerne d'autre part des dosages diagnostiques pour identifier des mutations dans des séquences d'acide nucléique de VIGF et des modifications de la concentration du polypeptide de VIGF.

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