Patched genes and their use

Details Patched genes and their use Patched genes and their use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2201887

Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.

On décrit des gènes PTC d'invertébrés et de vertébrés, y compris de murins et d'humains, ainsi que des procédés qui permettent d'isoler des gènes apparentés qui peuvent appartenir à d'espèces différentes ou à la même famille. La possibilité de réguler l'expression d'un gène PTC permet la compréhension du développement embryonnaire, la régulation cellulaire associée à la transduction de signaux par ce gène PTC, l'identification d'agonistes et d'antagonistes de la transduction de ces signaux, l'identification de ligands se liant à ce gène PTC, l'isolation de ligands, et les titrages permettant de déterminer les niveaux de transcription et d'expression du gène PTC.

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