C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01)
Patent
CA 2732401
The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using dental pulp stem cells as a source of somatic cells, the efficiency of establishment of human iPS cells by transfer of 3 or 4 factors can be improved dramatically. Additionally, dental pulp stem cells are easily available because they can be isolated and prepared from extracted wisdom teeth and teeth ex-tracted because of periodontal disease and the like, so that they can be used widely as a source of somatic cells for iPS cell banks.
La présente invention porte sur un procédé de production de cellules souches pluripotentes induites (iPS). Ce procédé consiste à amener une substance de re-programmation nucléaire en contact avec des cellules souches de pulpe dentaire. En utilisant des cellules souches de pulpe dentaire comme source de cellules somatiques, l'efficacité d'établissement de cellules iPS humaines par transfert de 3 ou 4 facteurs peut être améliorée de façon spectaculaire. De plus, on peut se procurer facilement les cellules souches de pulpe dentaire parce qu'elles peuvent être isolées et préparées à partir de dents de sagesse extraites et de dents extraites en raison d'une maladie parodontale et autre, de telle sorte qu'elles peuvent être largement utilisées comme source de cellules somatiques pour des banques de cellules iPS.
Kunisada Takahiro
Shibata Toshiyuki
Takahashi Kazutoshi
Takeda Tomoko
Tamaoki Naritaka
Fetherstonhaugh & Co.
Gifu University
Kyoto University
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