Therapy for andropause using estrogen agonists/antagonists...

Details Therapy for andropause using estrogen agonists/antagonists... Therapy for andropause using estrogen agonists/antagonists...

A - Human Necessities

61

K

A61K 31/568 (2006.01) A61K 31/565 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01) A61P 15/00 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2363935

Disclosed is a pharmaceutical composition for treatment of andropause and related conditions using a combination of an estrogen agonist/antagonist and testosterone. The estrogen agonist/antagonist may be a compound of the formula: Image wherein A is CH2 or NR; B, D and E are each CH or N; Y is phenyl, naphthyl, cycloalkyl or the like; Z1 is alkylene or the like; G is amino or the like; e is 0, 1 or 2, such as (-)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]- 5,6,7,8-tetrahydronaphthalene-2-ol.

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