Use of rom production and release inhibitors to treat and...

A - Human Necessities – 61 – K

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Details

A61K 31/675 (2006.01) A61K 31/4045 (2006.01) A61K 31/417 (2006.01) A61K 38/16 (2006.01) A61K 38/44 (2006.01) A61P 27/00 (2006.01)

Patent

CA 2480047

A method of treating or preventing intraocular damage caused by reactive oxygen metabolites is provided. The method includes identifying a subject presenting the symptoms of proliferative diabetic retinopathy; and administering to at least one eye of the subject a pharmaceutically acceptable solution containing an effective concentration of a compound effective to reduce the amount of ROM in an individual. The compounds effective to reduce the amount of ROM in an individual include histamine and histamine related compounds. The specific disease states characterized by intraocular damage caused by reactive oxygen metabolites include proliferative diabetic retinopathy, preproliferative diabetic retinopathy, proliferative retinopathy, age-related macular degeneration, retinitis pigmentosa, and macular holes. A pharmaceutical composition including a pharmaceutically acceptable ophthalmic solution containing an effective concentration of a compound effective to reduce the amount of ROM in an individual is likewise provided.

La présente invention concerne une méthode destinée au traitement ou à la prévention de dommages intraoculaires causés par des métabolites d'oxygène réactif. Ladite méthode consiste à identifier un sujet présentant les symptômes de la rétinopathie diabétique proliférative; et à administrer dans au moins un oeil du sujet une solution pharmaceutiquement acceptable contenant une concentration efficace d'un composé efficace pour réduire la quantité de ROM chez un individu. Parmi les composés efficaces pour réduire la quantité de ROM chez un individu, on trouve l'histamine et des composés associés à l'histamine. Parmi les états pathologiques spécifiques caractérisés par des dommages intraoculaires causés par des métabolites d'oxygène réactif, on trouve la rétinopathie diabétique proliférative, la rétinopathie proliférative, la dégénérescence maculaire liée à l'âge, la rétinite pigmentaire et les trous maculaires. La présente invention concerne également une composition pharmaceutique comprenant des gouttes opthalmiques pharmaceutiquement acceptables qui contiennent une concentration efficace d'un composé efficace pour réduire la quantité de ROM chez un individu.

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