Dental implant and production method for said implant

Details Dental implant and production method for said implant Dental implant and production method for said implant

A - Human Necessities

61

K

A61K 6/00 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2625975

The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing a dental implant of this type and to a specific composition, which can be used to produce a coating of this type.

L'invention concerne un implant dentaire présentant, au moins partiellement, un revêtement se trouvant en contact avec des tissus durs et/ou mous dans des zones de surface, à l'état implanté. Pour que l'agent actif bisphosphonate contenu dans le revêtement puisse être libéré et agir de façon commandée, et à la vitesse adéquate, dans les tissus environnants, le revêtement contient un bisphosphonate, des sels pharmaceutiquement acceptables respectifs ou des esters de celui-ci, et au moins un composant amphiphile choisi dans le groupe des C10-C30-alkyl-, alcényl-, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl- -carboxylates, -phosphates ou -sulfates ramifiés ou linéaires, substitués ou non, insaturés ou partiellement insaturés, ou des mélanges de ceux-ci, ou un composant polymère, ionique, soluble dans l'eau. L'invention concerne également un procédé de fabrication d'un tel implant dentaire et une composition spécifique pouvant être employée pour la fabrication d'un tel revêtement.

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