Stereotactic radiotreatment and prevention of restenosis

Details Stereotactic radiotreatment and prevention of restenosis Stereotactic radiotreatment and prevention of restenosis

A - Human Necessities

61

N

A61N 5/00 (2006.01) A61N 5/10 (2006.01)

Patent

CA 2295480

This invention is a method and apparatus for dynamic stereotactic radiotreatment and prevention of restenosis. A stent is implanted in a coronary artery following percutaneous trans-luminal coronary angio-plasty. Subsequent restenosis is minimized by external irradiation of the stent by ionizing radiation (40) such as gamma rays (42). The fact that the stent is significantly more opaque to x-rays than the surrounding tissue is exploited to track the stent using fluoroscopy, so that the ionizing radiation (40) can be aimed accurately at the stent. Preferably the fluoroscopic imaging (22), and the irradiation of the stent are synchronized with the patient's cardiac cycle. The external irradiation (40) may be performed hours or days after implanting the stent for prevention of restenosis, or weeks, or months after implanting the stent for treatment of restenosis, and may be fractionated.

L'invention concerne une méthode et un dispositif destinés à la radiothérapie stéréotaxique dynamique et à la prévention de la resténose. On implante un stent dans une artère coronaire après angioplastie coronarienne transluminale percutanée. On minimise la resténose ultérieure en irradiant le stent par voie externe avec des rayonnements ionisants (40), tels que des rayons gamma (42). On exploite le fait que le stent soit sensiblement plus opaque aux rayons X que le tissu environnant pour repérer le stent à la radioscopie, ce qui permet de diriger sur lui avec précision les rayonnements ionisants (40). De préférence, l'imagerie radioscopique (22) et l'irradiation du stent sont synchronisés avec le cycle cardiaque du patient. L'irradiation externe (40) peut se faire plusieurs heures ou jours après l'implantation du stent, en vue de la prévention de la resténose, ou bien plusieurs semaines ou mois après l'implantation, en vue du traitement de la resténose, et elle peut être fractionnée.

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