Inhibition of il-17 production

Details Inhibition of il-17 production Inhibition of il-17 production

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/24 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2501786

The invention concerns inhibition of the production of proinflammatory cytokine Interleukin-17 (IL-17) by T cells, using an antagonist of interleukin- 23 (IL-23). The invention further concerns the use of IL-23 antagonists in the treatment of inflammatory diseases characterized by the presence of elevated levels of IL-17. IL-23 antagonists include, without limitation, antibodies specifically binding to a subunit or IL-17 or an IL-17 receptor. The invention additionally concerns induction of IL-7 production by using an IL-23 agonist.

Cette invention concerne un procédé d'inhibition de la production de cytokine interleukine-17 (IL-17) pro-inflammatoire par les lymphocytes T faisant appel à un antagoniste de l'interleukine-23 (IL-23). Cette invention concerne également l'utilisation d'antagonistes d'IL-23 dans le traitement de maladies inflammatoires qui se caractérisent par la présence de niveaux élevés d'IL-17. Les antagonistes d'IL-23 comprennent un nombre illimité d'anticorps qui se lient spécifiquement à une unité secondaire ou IL-17 ou à un récepteur d'IL-17. Cette invention concerne en outre l'induction de la production d'IL-7 à l'aide d'un agoniste d'IL-23.

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