Form iii crystalline...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/34 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2220458

A novel crystalline form of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.- dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1- heptanoic acid hemi calcium salt designated Form III is characterized by its X- ray powder diffraction and/or solid state NMR is described, as well as methods for the preparation and pharmaceutical composition of the same, which is useful as an agent for treating hyperlipidemia and hypercholesterolemia.

Forme cristalline nouvelle d'hémi-sel de calcium d'acide [R-(R*,R*)]-2(4-fluorophényl)-.beta.,.delta.-dihydroxy-5-(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H-pyrrole-1-heptanoïque, désignée sous le nom de Forme III, caractérisée par sa diffraction des rayons X sous forme pulvérulente et/ou sa résonance magnétique nucléaire à l'état solide. Sont également décrits ses procédés de préparation et la composition pharmaceutique correspondante, utile comme agent de traitement de l'hyperlipidémie et de l'hypercholestérolémie.

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