C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/395 (2006.01) A61P 25/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 491/107 (2006.01)
Patent
CA 2737711
Compounds of formula (I): wherein variables B, G1, G2, G3, G4, E a, E b, E c, A1, A2, A3, A4, R6 and R PG and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Cette invention concerne des composés de formule I, dans laquelle les variables B, G1, G2, G3, G4, Ea, Eb, Ec, A1, A2, A3, A4, R6, RPG et Y sont telles que décrites ici. Ces composés sont antagonistes des récepteurs du CGRP et sont utilisés dans le traitement ou la prévention des maladies dans lesquelles le CGRP est impliqué, par exemple la migraine. Linvention concerne également des compositions pharmaceutiques comprenant ces composés et lutilisation de ces composés et de ces compositions dans la prévention ou le traitement de ces maladies dans lesquelles le CGRP est impliqué.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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