In vivo cell surface engineering

Details In vivo cell surface engineering In vivo cell surface engineering

A - Human Necessities

61

K

A61K 47/48 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2632682

The present invention provides methods and compositions for the in vivo engineering of cell surfaces, such as tumor cell surfaces, with one or more immune co-stimulatory polypeptides. The methods, compositions and engineered cells are useful, for example, to stimulate an immune response against the cells. When the engineered cell surfaces are tumor cell surfaces, the methods, compositions and engineered cells are useful for improving a patient's immune response against the cancer and for reducing tumor size and inhibiting tumor growth.

L'invention concerne des procédés et des compositions destinés à la modification in vivo de surfaces cellulaires, telles que des surfaces de cellules tumorales, au moyen d'un ou plusieurs polypeptides co-stimulatoires immuns. Les procédés, les compositions et les cellules modifiées sont utiles, par exemple, pour stimuler une réponse immune contre les cellules. Quand les surfaces cellulaires modifiées sont des surfaces cellulaires tumorales, les procédés, les compositions et les cellules modifiées sont utiles pour améliorer la réponse immune d'un patient contre le cancer et pour réduire la taille des tumeurs et pour inhiber la croissance tumorale.

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